In this talk, I will discuss several studies on the intonation of statements and questions in Quechua and Spanish varieties spoken in Peru and Bolivia. However, there has been relatively little research on the intonation of bilingual Quechua and Spanish (with some exceptions, e.g., O’Rourke, 2005), and the direction of cross-linguistic influence regarding intonation is less clear. For instance, Spanish has influenced the Quechua lexicon, morphology and (lexical) phonology (matter in Matras & Sakel’s (2007) terminology), and Quechua has influenced the conceptual organization (semantics and pragmatics) of Spanish (pattern in Matras & Sakel’s (2007) terminology) (Muysken & Muntendam, in press). Previous research on language contact in the Andes has shown cross-linguistic influence in different domains in Quechua and Spanish.